Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14268962 | 0.88 | TLR8 (0.54) | NCF1CYP1A2KDM4ERAB9ACYP2C19 | |
| SCHEMBL265139 | 0.85 | NCF1 (0.61) | NCF1CYP1A2KDM4ERAB9ACYP2C19 | |
| SCHEMBL18535317 | 0.84 | CYP1A2 (0.58) | NCF1CYP1A2KDM4ERAB9ACYP2C19 | |
| SCHEMBL6964689 | 0.82 | CYP1A2 (0.56) | NCF1CYP1A2KDM4ERAB9ACYP2C19 | |
| SCHEMBL28728112 | 0.82 | CYP1A2 (0.56) | NCF1CYP1A2KDM4ERAB9ACYP2C19 | |
| SCHEMBL6788358 | 0.82 | CYP2C19 (0.56) | NCF1CYP1A2KDM4ERAB9ACYP2C19 | |
| SCHEMBL8232676 | 0.79 | CYP1A2 (0.62) | NCF1CYP1A2KDM4ERAB9ACYP2C19 | |
| SCHEMBL1366357 | 0.79 | CYP1A2 (0.62) | NCF1CYP1A2KDM4ERAB9ACYP2C19 | |
| SCHEMBL6788451 | 0.79 | NCF1 (0.60) | NCF1CYP1A2RAB9ATAAR1HTT | |
| SCHEMBL6790022 | 0.79 | NCF1 (0.60) | NCF1CYP1A2KDM4ECYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825215-B2 | N-HYDROXY-2-(2-(((4-((2-METHYL-4-QUINOLINYL)METHOXY)PHENYL) -SULFONYL)METHYL)-2-PYRROLIDINYL)ACETAMIDE, FOR EXAMPLE AND OTHER QUINOLINE CONTAINING N-HYDROXYACETAMIDE DERIVATIVES | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-11-30 | — | — | US | disclosed |
| EP-1355901-A2 | 1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a) | Bristol-Myers Squibb Pharma Company (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002055516-A2 | 1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a) | BRISTOL MYERS SQUIBB CO (US) | 2002-07-18 | — | — | WO | disclosed |