Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402651 | 0.92 | HPGD (0.43) | HPGDHTTCYP2D6ALDH1A1RAB9A | |
| SCHEMBL2405040 | 0.85 | PKM (0.47) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2401319 | 0.80 | SMN1; SMN2 (0.41) | HPGDHTTALDH1A1RAB9ANPC1 | |
| SCHEMBL2400885 | 0.80 | ABL1 (0.46) | HPGDHTTALDH1A1RAB9ANPC1 | |
| SCHEMBL2399304 | 0.80 | FKBP1A (0.48) | HPGDALDH1A1RAB9AKDM4EMEN1 | |
| SCHEMBL2575305 | 0.79 | SMN1; SMN2 (0.45) | HPGDHTTCYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL2401534 | 0.78 | HPGD (0.42) | HPGDHTTALDH1A1RAB9ANPC1 | |
| SCHEMBL2401978 | 0.78 | RAB9A (0.45) | HPGDALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL2401537 | 0.78 | AVPR1A (0.43) | HPGDHTTALDH1A1SMN1; SMN2PKM | |
| SCHEMBL2402952 | 0.77 | HPGD (0.39) | HPGDHTTALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040192916-A1 | Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives and related treatment methods | GRUENENTHAL GMBH (DE) | 2004-09-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192916-A1 | Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives and related treatment methods | SULT1E1, CYP4B1, CYP3A4 | HPGD 679/4885HTT 3006/4885CYP2D6 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.