Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 16/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 14/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 14/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 10/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 10/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200444 | 0.88 | ADRA1A (0.60) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6785295 | 0.80 | ADRA1A (0.61) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6243274 | 0.79 | ADRA1D (0.47) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6275329 | 0.75 | OPRM1 (0.43) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6786591 | 0.74 | ADRA1A (0.60) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL7955897 | 0.71 | ADRA1A (0.68) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL9392182 | 0.71 | ADRA1A (0.67) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL7955959 | 0.71 | ADRA1A (0.67) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL7959467 | 0.70 | ADRA1A (0.63) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL7959478 | 0.70 | ADRA1A (0.63) | ADRA1AADRA1DADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727257-B1 | HYPOTENSIVE AGENTS FOR INTRAOCULAR PRESSURE; ANTICHOLESTEROL AGENTS; RELAXING URINARY TRACT TISSUE; BENIGN PROSTATIC HYPERPLASIA, IMPOTENCY, AND CARDIOVASCULAR DISORDERS; ANTIARRHYTHMIA AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-04-27 | — | — | US | disclosed |
| US-6268369-B1 | ALPHA SUB 1 INHIBITORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-07-31 | — | — | US | disclosed |
| US-6248747-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA WITH ANTAGONISTS SELECTIVE FOR CLONED HUMAN ALPHA-1C RECEPTORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-06-19 | — | — | US | disclosed |
| US-5942517-A | ANTAGONIST OF ALPHA(1C) RECEPTORS; TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0790826-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0790826-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996014846-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |