Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19787889 | 0.80 | MAPT (0.53) | KDM4ENPC1RAB9ASMN1; SMN2PBRM1 | |
| SCHEMBL29449194 | 0.73 | KDM4E (0.57) | KDM4ENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL11628053 | 0.70 | SMN1; SMN2 (0.51) | KDM4ENPC1RAB9ASMN1; SMN2PBRM1 | |
| SCHEMBL29511771 | 0.67 | SMN1; SMN2 (0.41) | KDM4ESMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| SCHEMBL29354440 | 0.67 | SMN1; SMN2 (0.39) | KDM4ESMN1; SMN2PBRM1L3MBTL1MAPT | |
| SCHEMBL4510784 | 0.67 | SMN1; SMN2 (0.39) | KDM4ESMN1; SMN2PBRM1L3MBTL1MAPT | |
| SCHEMBL1772021 | 0.67 | SMN1; SMN2 (0.61) | KDM4ERAB9ASMN1; SMN2PBRM1L3MBTL1 | |
| SCHEMBL19787891 | 0.66 | SMN1; SMN2 (0.39) | KDM4ENPC1SMN1; SMN2PBRM1L3MBTL1 | |
| SCHEMBL30649148 | 0.66 | TERT (0.36) | KDM4ESMN1; SMN2PBRM1L3MBTL1GAA | |
| SCHEMBL13852989 | 0.64 | KMT2A (0.41) | KDM4ESMN1; SMN2PBRM1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999065902-A1 | METHOD FOR PRODUCING 2,4-DIMETHYLCARBOLINE AND 2,4-DIMETHYLPYRIMIDO[1,2-a]INDOLE | BAYER AKTIENGESELLSCHAFT (DE) | 1999-12-23 | — | — | WO | claimed |
| US-6774236-B1 | METHYLBENZENEACETIC ACID ESTER DERIVATIVES AS CHEMICAL INTERMEDIATES | BAYER AKTIENGESELLSCHAFT (DE) | 2004-08-10 | — | — | US | disclosed |
| EP-0799829-B1 | Process for the preparation of enantiomerically pure cycloalkanoindole-, azaindole- and pyrimido [1,2a] indole carboxylic acids and their activated derivatives | BAYER AG (DE) | 2003-07-30 | — | — | EP | disclosed |
| WO-1999065902-A1 | METHOD FOR PRODUCING 2,4-DIMETHYLCARBOLINE AND 2,4-DIMETHYLPYRIMIDO[1,2-a]INDOLE | BAYER AKTIENGESELLSCHAFT (DE) | 1999-12-23 | — | — | WO | disclosed |
| WO-1999065902-A1 | METHOD FOR PRODUCING 2,4-DIMETHYLCARBOLINE AND 2,4-DIMETHYLPYRIMIDO[1,2-a]INDOLE | BAYER AKTIENGESELLSCHAFT (DE) | 1999-12-23 | — | — | WO | disclosed |
| WO-1999065902-A1 | METHOD FOR PRODUCING 2,4-DIMETHYLCARBOLINE AND 2,4-DIMETHYLPYRIMIDO[1,2-a]INDOLE | BAYER AKTIENGESELLSCHAFT (DE) | 1999-12-23 | — | — | WO | disclosed |
| US-5952498-A | SYNTHESIZING THE CHEMICAL INTERMEDIATES FOR ANTIATHEROSCLEROTICALLY ACTIVE DRUG | BAYER AKTIENGESELLSCHAFT (DE) | 1999-09-14 | — | — | US | disclosed |
| EP-0799829-A1 | Process for the preparation of enantiomerically pure cycloalkanoindole-, azaindole- and pyrimido [1,2a] indole carboxylic acids and their activated derivatives | BAYER AG (DE) | 1997-10-08 | — | — | EP | disclosed |