Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.91 |
| ▸ | MMP2 | P08253 | 6/20 | 0.74 |
| ▸ | ADAM17 | P78536 | 15/20 | 0.71 |
| ▸ | MMP9 | P14780 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7547767 | 1.00 | MMP13 (0.91) | MMP13MMP2ADAM17MMP9 | |
| Trifluoroacetic Acid SCHEMBL6785994 | 0.98 | MMP13 (0.88) | MMP13MMP2ADAM17MMP9 | |
| SCHEMBL6783379 | 0.96 | MMP13 (1.00) | MMP13MMP2ADAM17MMP9 | |
| SCHEMBL6788734 | 0.93 | MMP13 (0.95) | MMP13MMP2ADAM17MMP9 | |
| Trifluoroacetic Acid SCHEMBL6788954 | 0.92 | MMP13 (0.78) | MMP13MMP2ADAM17MMP9 | |
| Trifluoroacetic Acid SCHEMBL6795323 | 0.88 | ADAM17 (0.92) | MMP13MMP2ADAM17MMP9 | |
| Trifluoroacetic Acid SCHEMBL6788773 | 0.88 | MMP2 (0.88) | MMP13MMP2ADAM17MMP9 | |
| SCHEMBL6787256 | 0.88 | MMP13 (0.84) | MMP13MMP2ADAM17MMP9 | |
| Trifluoroacetic Acid SCHEMBL6787232 | 0.87 | MMP13 (0.70) | MMP13MMP2ADAM17MMP9 | |
| Trifluoroacetic Acid SCHEMBL6786563 | 0.87 | ADAM17 (0.91) | MMP13MMP2ADAM17MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825215-B2 | N-HYDROXY-2-(2-(((4-((2-METHYL-4-QUINOLINYL)METHOXY)PHENYL) -SULFONYL)METHYL)-2-PYRROLIDINYL)ACETAMIDE, FOR EXAMPLE AND OTHER QUINOLINE CONTAINING N-HYDROXYACETAMIDE DERIVATIVES | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-11-30 | — | — | US | disclosed |