Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.59 |
| ▸ | DRD2 | P14416 | 5/20 | 0.59 |
| ▸ | DRD3 | P35462 | 5/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792453 | 0.88 | DRD4 (0.64) | DRD4DRD2DRD3HTR1AHRH4 | |
| SCHEMBL6793112 | 0.81 | DRD2 (0.63) | DRD4DRD2DRD3HTR1AADRA2A | |
| SCHEMBL6787958 | 0.78 | KMT2A (0.59) | HRH4KMT2A | |
| SCHEMBL4823536 | 0.76 | DRD4 (0.59) | DRD4DRD2DRD3HTR1AADRA2A | |
| SCHEMBL6793465 | 0.76 | DRD4 (0.76) | DRD4DRD2DRD3HTR1AADRA2A | |
| SCHEMBL6793139 | 0.74 | DRD4 (0.77) | DRD4DRD2DRD3HTR1AADRA2A | |
| SCHEMBL21684646 | 0.74 | ALDH1A1 (0.58) | DRD4DRD2DRD3HTR1AADRA2A | |
| SCHEMBL4814827 | 0.74 | DRD4 (1.00) | DRD4DRD2DRD3HTR1AADRA2A | |
| SCHEMBL4810808 | 0.72 | DRD4 (1.00) | DRD4DRD2HTR1AGAAHTT | |
| SCHEMBL4520581 | 0.72 | KMT2A (0.61) | DRD4DRD2DRD3HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040198734-A1 | 2-(4-Aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine | PFIZER INC | 2004-10-07 | — | — | US | disclosed |
| US-20030100757-A1 | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine D4 receptor | PFIZER INC. | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100757-A1 | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine D4 receptor | DRD2, DRD3, DRD4 | DRD4 3/4885DRD2 1/4885DRD3 2/4885 |
| US-20040198734-A1 | 2-(4-Aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine | DRD2, DRD3, TPH1 | DRD4 6/4885DRD2 1/4885DRD3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.