Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | PPARA | Q07869 | 4/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6783348 | 0.88 | BCL2L1 (0.49) | PPARGPPARABCL2L1MCL1MMP2 | |
| SCHEMBL6790714 | 0.88 | ADAMTS4 (0.47) | PPARGPPARABCL2L1MCL1MMP2 | |
| SCHEMBL6794038 | 0.88 | BCL2L1 (0.47) | BCL2L1MCL1MMP2MMEMMP9 | |
| SCHEMBL6788518 | 0.85 | ALDH1A1 (0.53) | MMP2MMEMMP9MMP7 | |
| SCHEMBL7447715 | 0.85 | KMT2A (0.53) | CYP1A2GAACYP2C19TDP1 | |
| SCHEMBL6787286 | 0.85 | KMT2A (0.53) | CYP1A2GAACYP2C19TDP1 | |
| SCHEMBL6790296 | 0.84 | ENPP1 (0.54) | BCL2L1MCL1MMP2MMP9 | |
| SCHEMBL6783697 | 0.84 | CYP1A2 (0.45) | BCL2L1MCL1MMP2ADAMTS5MMP9 | |
| SCHEMBL6784512 | 0.81 | SMN1; SMN2 (0.48) | MMP2ADAMTS5MMP9CYP1A2GAA | |
| SCHEMBL7360995 | 0.79 | NPC1 (0.53) | MMP2ADAMTS5MMP9GAAMMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200398-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2002-05-02 | — | — | EP | claimed |
| WO-2001005756-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-01-25 | — | — | WO | claimed |
| US-6765003-B1 | ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, | PHARMACIA ITALIA, SPA (IT) | 2004-07-20 | — | — | US | disclosed |
| EP-1200398-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005756-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-01-25 | — | — | WO | disclosed |