Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 7/20 | 0.43 |
| ▸ | MMP1 | P03956 | 4/20 | 0.43 |
| ▸ | MMP3 | P08254 | 4/20 | 0.43 |
| ▸ | MMP13 | P45452 | 4/20 | 0.43 |
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.41 |
| ▸ | MMP14 | P50281 | 3/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6788890 | 0.88 | BCL2L1 (0.49) | BCL2L1MCL1MMP2MMP1MMP3 | |
| SCHEMBL6788751 | 0.88 | PPARG (0.50) | BCL2L1MCL1MMP2MMEMMP9 | |
| SCHEMBL6788518 | 0.85 | ALDH1A1 (0.53) | ADAMTS4MMP2MMP1MMP3MMP13 | |
| SCHEMBL6790714 | 0.83 | ADAMTS4 (0.47) | BCL2L1MCL1ADAMTS4MMP2MMP1 | |
| SCHEMBL6787277 | 0.83 | ALDH1A1 (0.46) | ADAMTS4MMP2MMP1MMP3MMP13 | |
| SCHEMBL6794468 | 0.78 | MMP2 (0.47) | BCL2L1MMP2MMP1MMP3MMP13 | |
| SCHEMBL6784814 | 0.77 | PRMT1 (0.52) | MMP2MMP3MMP13MMP9 | |
| SCHEMBL6783348 | 0.76 | BCL2L1 (0.49) | BCL2L1MCL1MMP2MMP1MMP3 | |
| SCHEMBL7555789 | 0.75 | MMP3 (0.55) | ADAMTS4MMP2MMP1MMP3MMP13 | |
| SCHEMBL6783697 | 0.75 | CYP1A2 (0.45) | BCL2L1MCL1MMP2MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765003-B1 | ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, | PHARMACIA ITALIA, SPA (IT) | 2004-07-20 | — | — | US | disclosed |