Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401146 | 0.86 | DRD2 (0.49) | IDO1DRD2DRD4DRD3SLC6A4 | |
| SCHEMBL6783710 | 0.81 | IDO1 (0.49) | IDO1SLC6A4HTR6MAP3K14HTR1A | |
| SCHEMBL11976872 | 0.76 | IDO1 (0.50) | IDO1DRD2DRD4DRD3SLC6A4 | |
| SCHEMBL25009464 | 0.76 | POLB (0.55) | IDO1DRD2DRD4DRD3HTR6 | |
| SCHEMBL13323651 | 0.75 | HTR6 (0.63) | IDO1SLC6A4HTR6MAP3K14HTR1A | |
| SCHEMBL28446100 | 0.75 | CHUK (0.56) | — | |
| SCHEMBL3574426 | 0.75 | IMPDH2 (0.58) | IDO1SLC6A4HTR6 | |
| SCHEMBL20846161 | 0.74 | HTR6 (0.51) | DRD2DRD4DRD3SLC6A4HTR6 | |
| SCHEMBL20846200 | 0.73 | EGFR (0.50) | DRD2DRD4DRD3SLC6A4HTR6 | |
| SCHEMBL22359655 | 0.73 | SLC6A4 (0.49) | IDO1SLC6A4HTR6MAP3K14HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809106-B1 | ANTIPROLIFERATION AGENTS; SUCH AS 4-(2-METHOXYPHENOXY)-ANILINO-3-CHLORO-6,7-DIMETHOXYQUINOLINE | ASTRAZENECA AB (SE) | 2004-10-26 | — | — | US | disclosed |
| EP-1178966-B1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| EP-1178966-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | AstraZeneca AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000068200-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2000-11-16 | — | — | WO | disclosed |