Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19470000 | 0.80 | OPRM1 (0.44) | MEN1KMT2ANPC1RAB9AOPRM1 | |
| SCHEMBL10322397 | 0.76 | HTR2A (0.58) | SMN1; SMN2GAAHPGDOPRM1CYP3A4 | |
| SCHEMBL340564 | 0.76 | HTR2A (0.58) | SMN1; SMN2GAAHPGDOPRM1CYP3A4 | |
| SCHEMBL29221795 | 0.75 | SMN1; SMN2 (0.66) | SMN1; SMN2GAAMEN1KMT2ANPC1 | |
| SCHEMBL21077981 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4201868 | 0.73 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2AOPRM1HTT | |
| SCHEMBL6017363 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2GAAMEN1KMT2ANPC1 | |
| SCHEMBL30463552 | 0.72 | OPRM1 (0.41) | SMN1; SMN2GAAMEN1KMT2ANPC1 | |
| SCHEMBL5592055 | 0.72 | NPSR1 (0.41) | NPC1RAB9AOPRM1 | |
| SCHEMBL5695520 | 0.71 | OPRM1 (0.49) | SMN1; SMN2MEN1KMT2AHPGDOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6815458-B2 | NERVOUS SYSTEM DISORDERS | ACADIA PHARMACEUTICALS, INC | 2004-11-09 | — | — | US | claimed |