Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 12/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092923 | 0.81 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL6094173 | 0.81 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL6790596 | 0.80 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL6790604 | 0.75 | CA12 (0.38) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL5648251 | 0.74 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL7145945 | 0.72 | PTGS2 (0.41) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL5644179 | 0.71 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL5644840 | 0.70 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL5667582 | 0.68 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL5647718 | 0.68 | PTGS2 (0.67) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806288-B1 | CYCLOOXYGENASE-2 MEDIATED DISORDERS; REDUCES INFLAMMATION; FEWER SIDE EFFECTS | G.D. SEARLE & CO. | 2004-10-19 | — | — | US | disclosed |