Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1658085 | 0.91 | ALDH1A1 (0.31) | KDM4EALDH1A1PKMHPGDPDPK1 | |
| Trifluoroacetic Acid SCHEMBL6792947 | 0.89 | CYP1A2 (0.38) | HPGDPDPK1CDK2NAMPT | |
| SCHEMBL6790796 | 0.88 | KDM4E (0.31) | KDM4EALDH1A1PKMHPGD | |
| Trifluoroacetic Acid SCHEMBL1655691 | 0.86 | CDK2 (0.32) | HPGDPDPK1CDK2NAMPT | |
| Trifluoroacetic Acid SCHEMBL6795264 | 0.86 | NPC1 (0.39) | SMN1; SMN2NAMPT | |
| Trifluoroacetic Acid SCHEMBL6791540 | 0.85 | CYP1A2 (0.34) | KDM4EHPGDPDPK1CDK2NAMPT | |
| Trifluoroacetic Acid SCHEMBL6800586 | 0.85 | NAMPT (0.44) | ALDH1A1HPGDSMN1; SMN2NAMPT | |
| Trifluoroacetic Acid SCHEMBL6793508 | 0.83 | CDK4 (0.33) | HPGDCDK2 | |
| Trifluoroacetic Acid SCHEMBL6793561 | 0.83 | CDK2 (0.32) | PDPK1CDK2 | |
| Trifluoroacetic Acid SCHEMBL6791633 | 0.83 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | KDM4E 2167/4885ALDH1A1 4449/4885PKM 383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.