Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6791633 | 0.96 | ALDH1A1 (0.44) | NAMPTTSHRALDH1A1HTR1AHTR2A | |
| Trifluoroacetic Acid SCHEMBL6795264 | 0.96 | NPC1 (0.39) | NAMPTROCK2TSHRSMN1; SMN2CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL6800303 | 0.91 | HTR1A (0.40) | NAMPTHTR1AHTR2ADRD3SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL1655691 | 0.89 | CDK2 (0.32) | NAMPTROCK2TSHRHSP90AA1HSP90AB1 | |
| Trifluoroacetic Acid SCHEMBL6794262 | 0.89 | SMN1; SMN2 (0.42) | ROCK2TSHRALDH1A1HSP90AA1HSP90AB1 | |
| Trifluoroacetic Acid SCHEMBL6791904 | 0.89 | ROCK2 (0.39) | NAMPTROCK2TSHRALDH1A1HSP90AA1 | |
| SCHEMBL6800589 | 0.88 | NAMPT (0.42) | NAMPTROCK2MAPK10MAPK14TSHR | |
| Trifluoroacetic Acid SCHEMBL6791540 | 0.88 | CYP1A2 (0.34) | NAMPTCYP1A2CYP3A4CYP2C9HPGD | |
| Trifluoroacetic Acid SCHEMBL6794578 | 0.88 | SMN1; SMN2 (0.45) | ROCK2ALDH1A1SMN1; SMN2HPGD | |
| Trifluoroacetic Acid SCHEMBL4263955 | 0.87 | ALDH1A1 (0.38) | ROCK2MAPK14ALDH1A1HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | NAMPT 658/4885ROCK2 317/4885MAPK10 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.