Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1655691 | 0.92 | CDK2 (0.32) | CYP1A2CYP3A4CYP2C9HPGDCYP2C19 | |
| Trifluoroacetic Acid SCHEMBL6792947 | 0.91 | CYP1A2 (0.38) | CYP1A2CYP3A4CYP2C9HPGDCYP2C19 | |
| Trifluoroacetic Acid SCHEMBL6795264 | 0.89 | NPC1 (0.39) | CYP1A2CYP2C9CYP2C19NAMPT | |
| SCHEMBL6791548 | 0.88 | CYP1A2 (0.33) | CYP1A2CYP3A4CYP2C9HPGDCYP2C19 | |
| Trifluoroacetic Acid SCHEMBL6792435 | 0.88 | PTGES (0.35) | PDPK1CDK2 | |
| Trifluoroacetic Acid SCHEMBL1655186 | 0.88 | KDM4C (0.34) | CYP1A2CYP3A4CYP2C9HPGDCYP2C19 | |
| Trifluoroacetic Acid SCHEMBL6800586 | 0.88 | NAMPT (0.44) | CYP1A2CYP3A4CYP2C9HPGDCYP2C19 | |
| Trifluoroacetic Acid SCHEMBL6792057 | 0.87 | ROCK2 (0.40) | POLBMAPK1CDK2 | |
| SCHEMBL1655696 | 0.86 | KDM4E (0.32) | CYP1A2CYP3A4CYP2C9HPGDCYP2C19 | |
| Trifluoroacetic Acid SCHEMBL6793508 | 0.86 | CDK4 (0.33) | CYP1A2CYP3A4CYP2C9HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | CYP1A2 1087/4885CYP3A4 2152/4885CYP2C9 1505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.