Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 6/20 | 0.39 |
| ▸ | HTR7 | P34969 | 6/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792849 | 0.91 | DRD3 (0.41) | DRD3FAAHHTR1AHTR7DRD2 | |
| SCHEMBL6789354 | 0.86 | HTR1A (0.47) | DRD3FAAHHTR1AHTR7DRD2 | |
| SCHEMBL6791990 | 0.84 | DRD3 (0.46) | DRD3FAAHHTR1AHTR7DRD2 | |
| SCHEMBL7048481 | 0.83 | SIGMAR1 (0.43) | HTR1AHTR7 | |
| SCHEMBL6777478 | 0.83 | HTR1A (0.49) | DRD3HTR1AHTR7DRD2 | |
| SCHEMBL6795181 | 0.80 | DRD3 (0.46) | DRD3FAAHHTR1AHTR7DRD2 | |
| SCHEMBL7049639 | 0.79 | SIGMAR1 (0.43) | DRD3HTR7DRD5DRD4 | |
| SCHEMBL6772241 | 0.79 | HTR1A (0.42) | DRD3HTR1AHTR7DRD2DRD4 | |
| SCHEMBL6790535 | 0.79 | HTR1A (0.50) | DRD3HTR1AHTR7DRD2DRD5 | |
| SCHEMBL6766347 | 0.77 | APEX1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |