Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791990 | 0.89 | DRD3 (0.46) | HTR1ADRD3FAAHHTR7DRD2 | |
| SCHEMBL6792849 | 0.87 | DRD3 (0.41) | HTR1ADRD3FAAHHTR7DRD2 | |
| SCHEMBL6790993 | 0.86 | DRD3 (0.40) | HTR1ADRD3FAAHHTR7DRD2 | |
| SCHEMBL6795181 | 0.85 | DRD3 (0.46) | HTR1ADRD3FAAHHTR7DRD2 | |
| SCHEMBL7051788 | 0.81 | SIGMAR1 (0.43) | — | |
| SCHEMBL6790535 | 0.81 | HTR1A (0.50) | HTR1ADRD3HTR7DRD2 | |
| SCHEMBL6792470 | 0.80 | HTR7 (0.45) | HTR1ADRD3HTR7DRD2DRD4 | |
| SCHEMBL6793341 | 0.80 | HTR1A (0.46) | HTR1ADRD3HTR7DRD2DRD4 | |
| SCHEMBL6800314 | 0.80 | HTR1A (0.46) | HTR1ADRD3HTR7DRD2 | |
| SCHEMBL6789349 | 0.80 | HTR7 (0.45) | HTR1ADRD3HTR7DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |