Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092646 | 0.78 | PTGS2 (0.79) | PTGS2PTGS1 | |
| SCHEMBL6092640 | 0.78 | PTGS2 (0.79) | PTGS2PTGS1 | |
| SCHEMBL6791159 | 0.75 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL6791161 | 0.75 | PTGS2 (0.56) | PTGS2PTGS1DRD5P2RY6 | |
| SCHEMBL5642882 | 0.67 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL5644512 | 0.67 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL5647713 | 0.67 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL7146261 | 0.65 | PTGS2 (0.53) | PTGS2PTGS1DRD5P2RY6 | |
| SCHEMBL5668105 | 0.64 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL6790604 | 0.64 | CA12 (0.38) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806288-B1 | CYCLOOXYGENASE-2 MEDIATED DISORDERS; REDUCES INFLAMMATION; FEWER SIDE EFFECTS | G.D. SEARLE & CO. | 2004-10-19 | — | — | US | disclosed |