Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680604 | 0.86 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL28430420 | 0.86 | KDM4E (0.63) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL679402 | 0.82 | KDM4E (0.57) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL3410900 | 0.78 | GABRA2 (0.54) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL4985090 | 0.77 | ALDH1A1 (0.50) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL19511981 | 0.76 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL199471 | 0.76 | MAPT (1.00) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL69251 | 0.76 | TSHR (0.63) | MAPTALDH1A1HPGDGAAGABRA2 | |
| SCHEMBL19429727 | 0.75 | MAPT (0.58) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL4980883 | 0.75 | MAPT (0.48) | MAPTALDH1A1KDM4EHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423366-B | Preparation method of pirfenidone | 山东汇海医药化工有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-111423366-A | Preparation method of pirfenidone | 山东汇海医药化工有限公司 | 2020-07-17 | — | — | CN | disclosed |
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |