Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6792057 | 0.90 | ROCK2 (0.40) | ROCK2DGAT2POLBCYP2D6TP53 | |
| SCHEMBL1655963 | 0.89 | ROCK2 (0.39) | ROCK2ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL6791548 | 0.89 | CYP1A2 (0.33) | POLBALDH1A1TSHRMAPK1HSD17B10 | |
| SCHEMBL1655698 | 0.87 | CYP1A2 (0.30) | — | |
| SCHEMBL6792951 | 0.84 | CYP1A2 (0.37) | POLBMAPK1 | |
| SCHEMBL6795268 | 0.84 | NPC1 (0.38) | SMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL6787473 | 0.83 | ALDH1A1 (0.37) | ROCK2POLBALDH1A1TSHRHSD17B10 | |
| SCHEMBL6800589 | 0.83 | NAMPT (0.42) | ROCK2ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL4271422 | 0.82 | ROCK2 (0.31) | ROCK2AURKACCNA2CDK2CCNA1 | |
| SCHEMBL1655634 | 0.82 | LMNA (0.35) | ALDH1A1SMN1; SMN2TSHRMAPK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | ROCK2 317/4885DGAT2 2365/4885POLB 2849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.