Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6792169 | 1.00 | HTR5A (0.34) | HTR5AHTR1ADRD2DRD4HTR1D | |
| Trifluoroacetic Acid SCHEMBL6793889 | 0.96 | HTR1A (0.33) | HTR5AHTR1ADRD2DRD4HTR1D | |
| Trifluoroacetic Acid SCHEMBL6793894 | 0.96 | HTR1A (0.33) | HTR5AHTR1ADRD2DRD4HTR1D | |
| SCHEMBL6792172 | 0.90 | AURKA (0.32) | HTR5AHTR1ADRD2DRD4HTR1D | |
| Trifluoroacetic Acid SCHEMBL6787894 | 0.88 | HTR5A (0.39) | HTR5AHTR1ADRD2DRD4HTR1D | |
| Trifluoroacetic Acid SCHEMBL6787890 | 0.88 | HTR5A (0.39) | HTR5AHTR1ADRD2DRD4HTR1D | |
| SCHEMBL6793893 | 0.86 | AURKA (0.30) | CDK2AURKACCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6794198 | 0.86 | CDK2 (0.40) | CDK2AURKACCNA2CCNA1PDPK1 | |
| Trifluoroacetic Acid SCHEMBL6794213 | 0.86 | CDK2 (0.40) | CDK2AURKACCNA2CCNA1PDPK1 | |
| Trifluoroacetic Acid SCHEMBL1656607 | 0.81 | CDK2 (0.36) | HTR5AHTR1ADRD2DRD4HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | HTR5A 2230/4885HTR1A 3019/4885DRD2 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.