Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | HTR5A | P47898 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793893 | 0.96 | AURKA (0.30) | AURKACCNA2CDK2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6792174 | 0.90 | HTR5A (0.34) | AURKACCNA2CDK2CCNA1HTR1A | |
| Trifluoroacetic Acid SCHEMBL6792169 | 0.90 | HTR5A (0.34) | AURKACCNA2CDK2CCNA1HTR1A | |
| SCHEMBL6787892 | 0.89 | HTR1A (0.35) | AURKACCNA2CDK2CCNA1HTR1A | |
| SCHEMBL6794205 | 0.87 | CDK2 (0.38) | AURKACCNA2CDK2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6793894 | 0.86 | HTR1A (0.33) | AURKACCNA2CDK2CCNA1HTR1A | |
| Trifluoroacetic Acid SCHEMBL6793889 | 0.86 | HTR1A (0.33) | AURKACCNA2CDK2CCNA1HTR1A | |
| SCHEMBL1656609 | 0.82 | CDK2 (0.35) | AURKACCNA2CDK2CCNA1 | |
| SCHEMBL4259042 | 0.81 | HTR5A (0.33) | AURKACCNA2CDK2CCNA1HTR1A | |
| SCHEMBL4263121 | 0.79 | ROCK2 (0.37) | AURKACCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | AURKA 341/4885CCNA2 270/4885CDK2 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.