Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | EPOR | P19235 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616760 | 0.84 | KDM4E (0.66) | KDM4EALDH1A1SMN1; SMN2MAOBBCHE | |
| SCHEMBL3616763 | 0.84 | KDM4E (0.66) | KDM4EALDH1A1SMN1; SMN2MAOBBCHE | |
| SCHEMBL16167352 | 0.84 | CYP3A4 (0.51) | KDM4EALDH1A1SMN1; SMN2ALOX5ALOX5AP | |
| SCHEMBL16167358 | 0.84 | CYP3A4 (0.51) | KDM4EALDH1A1SMN1; SMN2ALOX5ALOX5AP | |
| SCHEMBL1665199 | 0.84 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2PDGFRBPDGFRA | |
| SCHEMBL6742203 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2PDGFRBPDGFRA | |
| SCHEMBL14732611 | 0.82 | TDP1 (0.43) | KDM4EALDH1A1SMN1; SMN2PDGFRBPDGFRA | |
| SCHEMBL6792937 | 0.82 | BCL9 (0.53) | KDM4EALDH1A1SMN1; SMN2PDGFRBPDGFRA | |
| SCHEMBL421378 | 0.81 | BCL9 (0.53) | KDM4EALDH1A1SMN1; SMN2PDGFRBPDGFRA | |
| SCHEMBL28432983 | 0.80 | ACHE (0.51) | KDM4EALDH1A1SMN1; SMN2PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122870-A1 | Treatment Of Ischemia-Reperfusion Injury | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122870-A1 | Treatment Of Ischemia-Reperfusion Injury | SPHK1, SPHK2, S1PR2 | KDM4E 3842/4885ALDH1A1 863/4885SMN1; SMN2 1209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.