Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23081442 | 0.85 | CCNT1 (0.42) | METPLK4NTRK1RETAXL | |
| SCHEMBL680085 | 0.84 | S1PR4 (0.44) | CYP11B1CYP11B2CYP19A1METPLK4 | |
| SCHEMBL680355 | 0.84 | PLK4 (0.53) | METPLK4NTRK1RETAXL | |
| SCHEMBL680022 | 0.84 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP19A1METPLK4 | |
| SCHEMBL680514 | 0.83 | PLK4 (0.41) | METPLK4NTRK1RETAXL | |
| SCHEMBL680923 | 0.81 | CYP11B1 (0.40) | CYP11B1CYP11B2CYP19A1METHSPB1 | |
| SCHEMBL29487166 | 0.80 | HSPB1 (0.44) | METPLK4NTRK1RETAXL | |
| SCHEMBL679255 | 0.80 | HSPB1 (0.44) | METPLK4NTRK1RETAXL | |
| SCHEMBL679110 | 0.80 | SERPINE1 (0.43) | METPLK4NTRK1RETAXL | |
| SCHEMBL680501 | 0.80 | SCN9A (0.43) | METPLK4NTRK1RETAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |