Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 9/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MST1R | Q04912 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679247 | 0.84 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP19A1METAXL | |
| SCHEMBL23081429 | 0.83 | AXL (0.41) | METAXLMKNK1MKNK2PLK4 | |
| SCHEMBL680695 | 0.83 | AXL (0.41) | METAXLMKNK1MKNK2PLK4 | |
| SCHEMBL680039 | 0.82 | PLK4 (0.55) | METAXLMKNK1MKNK2PLK4 | |
| SCHEMBL680999 | 0.81 | PLK4 (0.42) | METAXLMKNK1MKNK2PLK4 | |
| SCHEMBL680251 | 0.77 | FGFR1 (0.45) | CYP11B1CYP11B2CYP19A1METAXL | |
| SCHEMBL680838 | 0.77 | SCN9A (0.45) | METAXLMKNK1MKNK2PLK4 | |
| SCHEMBL1137102 | 0.77 | MET (0.58) | CYP11B1CYP11B2CYP19A1METAXL | |
| SCHEMBL680681 | 0.75 | CACNA1H (0.42) | METAXLMKNK1MKNK2PLK4 | |
| SCHEMBL680392 | 0.75 | MAPK1 (0.35) | METAXLMKNK1MKNK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |