Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 2/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679247 | 0.84 | CYP11B1 (0.47) | S1PR4HSPB1KDRPLK4NTRK1 | |
| SCHEMBL23081442 | 0.84 | CCNT1 (0.42) | S1PR4HSPB1KDRPLK4NTRK1 | |
| SCHEMBL680695 | 0.84 | AXL (0.41) | KDRPLK4NTRK1RETMET | |
| SCHEMBL680355 | 0.83 | PLK4 (0.53) | S1PR4HSPB1KDRPLK4NTRK1 | |
| SCHEMBL680020 | 0.82 | EGFR (0.39) | S1PR4HSPB1KDRGRM2CYP11B2 | |
| SCHEMBL680514 | 0.80 | PLK4 (0.41) | S1PR4HSPB1KDRPLK4NTRK1 | |
| SCHEMBL679255 | 0.80 | HSPB1 (0.44) | S1PR4HSPB1KDRPLK4NTRK1 | |
| SCHEMBL29487166 | 0.80 | HSPB1 (0.44) | S1PR4HSPB1KDRPLK4NTRK1 | |
| SCHEMBL679474 | 0.77 | ALDH1A1 (0.44) | S1PR4HSPB1KDRPLK4NTRK1 | |
| SCHEMBL680501 | 0.77 | SCN9A (0.43) | S1PR4HSPB1KDRPLK4NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |