Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 11/20 | 0.49 |
| ▸ | LMNA | P02545 | 8/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529826 | 0.85 | PDE3B (0.70) | PDE3BPDE3AKCNH2CYP11B2TP53 | |
| SCHEMBL9038679 | 0.83 | PDE3B (0.70) | PDE3BPDE3AALDH1A1KCNH2CYP11B2 | |
| SCHEMBL4322811 | 0.80 | PDE3B (1.00) | PDE3BPDE3ATSHRALDH1A1KCNH2 | |
| SCHEMBL9038866 | 0.80 | PDE3B (0.84) | PDE3BPDE3ATSHRALDH1A1KCNH2 | |
| SCHEMBL29424272 | 0.80 | PDE3B (1.00) | PDE3BPDE3ATSHRALDH1A1KCNH2 | |
| SCHEMBL9672059 | 0.80 | PDE3B (0.64) | PDE3BPDE3ATSHRALDH1A1KCNH2 | |
| SCHEMBL9528352 | 0.80 | PDE3B (0.68) | PDE3BPDE3AKCNH2CYP11B2MEN1 | |
| SCHEMBL9039619 | 0.79 | PDE3B (0.72) | PDE3BPDE3ATSHRALDH1A1KCNH2 | |
| SCHEMBL8553283 | 0.79 | PDE3B (0.88) | PDE3BPDE3ATSHRALDH1A1KCNH2 | |
| SCHEMBL9671568 | 0.79 | KCNH2 (0.64) | PDE3BPDE3ATSHRALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699857-B1 | ANEMIA | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-02 | — | — | US | disclosed |