Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29424272 | 0.84 | PDE3B (1.00) | PDE3BPDE3AALDH1A1TSHRKCNH2 | |
| SCHEMBL4322811 | 0.84 | PDE3B (1.00) | PDE3BPDE3AALDH1A1TSHRKCNH2 | |
| SCHEMBL8553283 | 0.83 | PDE3B (0.88) | PDE3BPDE3AALDH1A1TSHRKCNH2 | |
| SCHEMBL9529826 | 0.82 | PDE3B (0.70) | PDE3BPDE3AKCNH2LMNATP53 | |
| SCHEMBL9038679 | 0.82 | PDE3B (0.70) | PDE3BPDE3AALDH1A1KCNH2LMNA | |
| SCHEMBL9528728 | 0.82 | PDE3B (0.95) | PDE3BPDE3AALDH1A1TSHRKCNH2 | |
| SCHEMBL9038866 | 0.81 | PDE3B (0.84) | PDE3BPDE3AALDH1A1TSHRKCNH2 | |
| SCHEMBL8555995 | 0.80 | PDE3B (0.88) | PDE3BPDE3AALDH1A1TSHRKCNH2 | |
| SCHEMBL8552796 | 0.80 | PDE3B (0.88) | PDE3BPDE3AALDH1A1TSHRKCNH2 | |
| SCHEMBL6792537 | 0.79 | PDE3B (0.67) | PDE3BPDE3AALDH1A1TSHRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530657-B1 | Process for the separation of enantiomers of 5-hetaryl-1,3,4-thiadiazinone | MERCK PATENT GMBH (DE) | 1996-11-06 | — | — | EP | disclosed |
| US-5206363-A | PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF 5-HETEROARYL-1,3,4-THIADIAZINONES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-04-27 | — | — | US | disclosed |
| EP-0530657-A1 | Process for the separation of enantiomers of 5-hetaryl-1,3,4-thiadiazinone | MERCK PATENT GmbH (DE) | 1993-03-10 | — | — | EP | disclosed |