Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532096 | 0.91 | PDE3B (0.64) | PDE3BPDE3AKCNH2KDM4EPDE4A | |
| SCHEMBL9529826 | 0.86 | PDE3B (0.70) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9038679 | 0.84 | PDE3B (0.70) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9528728 | 0.84 | PDE3B (0.95) | PDE3BPDE3AKCNH2KDM4EPDE4A | |
| SCHEMBL4322811 | 0.81 | PDE3B (1.00) | PDE3BPDE3AKCNH2KDM4EPDE4A | |
| SCHEMBL29424272 | 0.81 | PDE3B (1.00) | PDE3BPDE3AKCNH2KDM4EPDE4A | |
| SCHEMBL9038866 | 0.81 | PDE3B (0.84) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL8553283 | 0.80 | PDE3B (0.88) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL6792537 | 0.80 | PDE3B (0.67) | PDE3BPDE3AKCNH2CYP11B2MEN1 | |
| SCHEMBL9039084 | 0.79 | PDE3B (0.61) | PDE3BPDE3AKCNH2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294647-B1 | THIADIAZINONES | MERCK PATENT GmbH (DE) | 1993-07-21 | — | — | EP | disclosed |
| EP-0358290-B1 | 2-Oxa-bicyclo[2.2.1]heptane derivatives and medicines containing these compounds | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |