SCHEMBL6792547

SCHEMBL6792547

CCCN(CF)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.45
TP53 P04637 2/20 0.40
CNR2 P34972 2/20 0.39
TAAR1 Q96RJ0 1/20 0.39
ESR1 P03372 1/20 0.38
NPSR1 Q6W5P4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
HTR7 P34969 1/20 0.37
MAPT P10636 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GLA P06280 1/20 0.36
ACHE P22303 1/20 0.36
MEN1 O00255 1/20 0.36
HTT P42858 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NR1H2 P55055 1/20 0.36
NR1H3 Q13133 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL411733 0.86 TSHR (0.52) TSHRTP53CNR2TAAR1ESR1
SCHEMBL6789628 0.84 NPC1 (0.47) TSHRCNR2ALDH1A1NR1H2NR1H3
SCHEMBL5716084 0.84 NPC1 (0.47) TSHRCNR2ALDH1A1NR1H2NR1H3
Water SCHEMBL31498994 0.84 TSHR (0.50) TSHRTP53CNR2TAAR1ESR1
Hydrochloric Acid SCHEMBL2142184 0.84 TSHR (0.50) TSHRTP53CNR2TAAR1ESR1
Nitrogen SCHEMBL4599415 0.82 TSHR (0.48) TSHRTP53CNR2TAAR1ESR1
SCHEMBL2917098 0.82 TSHR (0.59) TSHRTP53CNR2TAAR1L3MBTL1
Ammonia Solution, Strong SCHEMBL11317315 0.80 TSHR (0.57) TSHRTP53CNR2TAAR1L3MBTL1
Diethylaniline SCHEMBL18092109 0.80 TSHR (0.57) TSHRTP53CNR2TAAR1L3MBTL1
SCHEMBL95956 0.78 TSHR (0.45) TSHRTP53CNR2TAAR1ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012075232-A1 OPIOID RECEPTOR LIGANDS AND METHODS OF USING AND MAKING THE SAME TREVENA, INC. (US) 2012-06-07 WO disclosed
US-6822057-B2 OLEFIN POLYMERIZATION CATALYST SYSTEM IS A REACTION PRODUCT OF A METALLOCENES AND A COCATALYST CONTAINING FLUOROARYL SUBSTITUTED SECONDARY AMINE OR PHSOPHINE COMPOUND AND AN ANION CONTAINING GROUP 13 ELEMENT WHICH IS NONCOORDINATIG EXXON MOBIL CHEMICAL PATENTS INC. 2004-11-23 US disclosed
US-6489480-B2 COORDINATION POLYMERIZATION CATALYST FOR ALPHA-OLEFINS EXXONMOBIL CHEMICAL PATENTS INC. 2002-12-03 US disclosed
US-20020115806-A1 Olefin polymerization catalysts derived from Group-15 cationic compounds and processes using them EXXONMOBIL CHEMICAL PATENTS INC. 2002-08-22 US disclosed
US-20020111265-A1 GROUP-15 CATIONIC COMPOUNDS FOR OLEFIN POLYMERIZATION CATALYSTS EXXONMOBIL CHEMICAL PATENTS INC. 2002-08-15 US disclosed