Sugi Predict

Sugi Predict / Compounds / SCHEMBL6792890

SCHEMBL6792890

SCHEMBL6792890

O=C1CCCc2cn[nH]c21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD4 P21917 5/20 0.50
▸ DRD2 P14416 3/20 0.47
▸ HTR2A P28223 1/20 0.47
▸ HTR2C P28335 1/20 0.47
▸ HTR2B P41595 1/20 0.47
▸ MAPK10 P53779 6/20 0.46
▸ RIPK1 Q13546 4/20 0.46
▸ KDR P35968 2/20 0.46
▸ AURKA O14965 2/20 0.41
▸ PLK4 O00444 2/20 0.41
▸ DAPK3 O43293 2/20 0.41
▸ PIM1 P11309 2/20 0.41
▸ PDGFRA P16234 2/20 0.41
▸ LTK P29376 2/20 0.41
▸ MAP2K2 P36507 2/20 0.41
▸ FLT3 P36888 2/20 0.41
▸ MAPK8 P45983 2/20 0.41
▸ MAPK9 P45984 2/20 0.41
▸ CSNK1A1 P48729 2/20 0.41
▸ CDK8 P49336 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21614796 0.75 DRD4 (0.50) DRD4DRD2HTR2AHTR2CHTR2B
SCHEMBL7377305 0.75 PNMT (0.35) DRD4DRD2HTR2AHTR2CHTR2B
SCHEMBL7373377 0.75 DRD4 (0.42) DRD4DRD2HTR2AHTR2CHTR2B
SCHEMBL9594487 0.71 DRD4 (0.46) DRD4DRD2HTR2AHTR2CHTR2B
SCHEMBL21614784 0.71 DRD4 (0.46) DRD4DRD2HTR2AHTR2CHTR2B
SCHEMBL3078318 0.71 LTK (0.36) DRD4DRD2HTR2AHTR2CHTR2B
SCHEMBL7229902 0.71 LTK (0.68) DRD4DRD2HTR2AHTR2CHTR2B
SCHEMBL21612400 0.70 DRD4 (0.42) DRD4DRD2HTR2AHTR2CHTR2B
SCHEMBL21612401 0.70 DRD4 (0.42) DRD4DRD2HTR2AHTR2CHTR2B
SCHEMBL5763909 0.69 PARP10 (0.41) DRD4DRD2HTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583858-B2 TDO2 inhibitors GENENTECH, INC. (US) 2026-03-24 — — US disclosed
US-12358887-B2 IKAROS Zinc Finger Family degraders and uses thereof GILEAD SCIENCES, INC. (US) 2025-07-15 — — US disclosed
CN-119661516-A Bicyclic heterocyclic compounds, preparation method and medical application thereof 华润医药研究院（深圳）有限公司 2025-03-21 — — CN disclosed
EP-4464703-A2 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF Gilead Sciences, Inc. (US) 2024-11-20 — — EP disclosed
EP-4245756-B1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF GILEAD SCIENCES INC (US) 2024-10-09 — — EP disclosed
EP-3394068-B1 TDO2 INHIBITORS GENENTECH INC (US) 2024-09-11 — — EP disclosed
US-11897862-B2 IKAROS zinc finger family degraders and uses thereof GILEAD SCIENCES, INC. (US) 2024-02-13 — — US disclosed
WO-2023240267-A2 COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF SIONNA THERAPEUTICS (US) 2023-12-14 — — WO disclosed
US-20230373950-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF GILEAD SCIENCES, INC. 2023-11-23 — — US disclosed
US-20230295111-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF GILEAD SCIENCES, INC. 2023-09-21 — — US disclosed
WO-2017107979-A1 TDO2 INHIBITORS GENENTECH, INC. (US) 2017-06-29 — — WO disclosed
WO-2017107979-A1 TDO2 INHIBITORS GENENTECH, INC. (US) 2017-06-29 — — WO disclosed
US-20160304496-A1 INDAZOLONES AS MODULATORS OF TNF SIGNALING ABBVIE INC. 2016-10-20 — — US disclosed
WO-2016168633-A1 INDAZOLONES AS MODULATORS OF TNF SIGNALING ABBVIE INC. (US) 2016-10-20 — — WO disclosed
WO-2016168633-A1 INDAZOLONES AS MODULATORS OF TNF SIGNALING ABBVIE INC. (US) 2016-10-20 — — WO disclosed
US-20160304496-A1 INDAZOLONES AS MODULATORS OF TNF SIGNALING ABBVIE INC. 2016-10-20 — — US disclosed
US-20160304496-A1 INDAZOLONES AS MODULATORS OF TNF SIGNALING ABBVIE INC. 2016-10-20 — — US disclosed
US-20040127492-A1 Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 PHARMACIA CORPORATION 2004-07-01 — — US disclosed
EP-1177185-A1 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.p.A. (IT) 2002-02-06 — — EP disclosed
WO-2000069846-A1 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2000-11-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12358887-B2 IKAROS Zinc Finger Family degraders and uses thereof IKZF2, IKZF1, IKZF3 DRD4 4802/4885DRD2 4825/4885HTR2A 3688/4885
US-12583858-B2 TDO2 inhibitors TDO2, IDO2, TPH2 DRD4 2527/4885DRD2 768/4885HTR2A 17/4885
US-20230373950-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF IKZF2, IKZF1, IKZF3 DRD4 4802/4885DRD2 4825/4885HTR2A 3688/4885
US-20160304496-A1 INDAZOLONES AS MODULATORS OF TNF SIGNALING TNF, CD40, TNFRSF1A DRD4 970/4885DRD2 1049/4885HTR2A 1326/4885
US-20040127492-A1 Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 MKNK2, MAPKAPK2, MAP3K2 DRD4 4853/4885DRD2 4396/4885HTR2A 1489/4885
US-11897862-B2 IKAROS zinc finger family degraders and uses thereof IKZF2, IKZF1, IKZF3 DRD4 4802/4885DRD2 4825/4885HTR2A 3688/4885
US-20230295111-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF IKZF2, IKZF1, IKZF3 DRD4 4802/4885DRD2 4825/4885HTR2A 3688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.