Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 2/20 | 0.32 |
| ▸ | SKP1 | P63208 | 2/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6794800 | 0.91 | DRD2 (0.35) | ADORA3ADORA2ADRD2IDO1CYP11B1 | |
| SCHEMBL6792545 | 0.86 | CDK4 (0.36) | CDK4CCNA2CDK2CCND3CCNA1 | |
| SCHEMBL6791026 | 0.83 | SMN1; SMN2 (0.42) | CDK4CCNA2CDK2CCND3CCNA1 | |
| SCHEMBL6789045 | 0.82 | MAPT (0.34) | CDK4CCNA2CDK2CCND3CCNA1 | |
| SCHEMBL6794542 | 0.82 | CCNA2 (0.40) | ADORA3ADORA2ACDK4CCNA2CDK2 | |
| SCHEMBL6794919 | 0.81 | OPRD1 (0.35) | CDK4CCNA2CDK2CCND3CCNA1 | |
| SCHEMBL6798838 | 0.80 | ADORA1 (0.35) | ADORA3ADORA2AADORA1DRD2IDO1 | |
| SCHEMBL6794857 | 0.80 | CYP11B1 (0.38) | ADORA3ADORA2ACDK4CCNA2CDK2 | |
| SCHEMBL6794135 | 0.79 | CDK4 (0.38) | ADORA3ADORA2ACDK4CCNA2CDK2 | |
| SCHEMBL6792068 | 0.79 | MEN1 (0.36) | ADORA3CDK4CCNA2CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | ADORA3 2377/4885ADORA2A 1092/4885CDK4 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.