Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.32 |
| ▸ | RELA | Q04206 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791026 | 0.88 | SMN1; SMN2 (0.42) | ALDH1A1HPGDKDM4EHSD17B10CDK4 | |
| SCHEMBL6792545 | 0.88 | CDK4 (0.36) | ALDH1A1HPGDKDM4EHSD17B10CDK4 | |
| SCHEMBL6789045 | 0.83 | MAPT (0.34) | ALDH1A1HPGDKDM4EHSD17B10CDK4 | |
| SCHEMBL6792969 | 0.81 | ADORA3 (0.35) | CDK4CCNA2CDK2CCND3CCNA1 | |
| SCHEMBL6792068 | 0.79 | MEN1 (0.36) | ALDH1A1CDK4CCNA2CDK2CCND3 | |
| SCHEMBL6794842 | 0.78 | OPRD1 (0.35) | OPRD1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL6793803 | 0.77 | AURKA (0.51) | ALDH1A1HPGDKDM4EHSD17B10CDK4 | |
| SCHEMBL6791186 | 0.76 | BRAF (0.36) | OPRD1CDK4CCNA2CDK2CCND3 | |
| SCHEMBL6794835 | 0.75 | OPRD1 (0.35) | OPRD1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL6792323 | 0.74 | SMN1; SMN2 (0.42) | ALDH1A1HPGDKDM4EHSD17B10CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | OPRD1 3185/4885ALDH1A1 4449/4885HPGD 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.