Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | DRD4 | P21917 | 4/20 | 0.61 |
| ▸ | DRD3 | P35462 | 4/20 | 0.61 |
| ▸ | HRH2 | P25021 | 3/20 | 0.61 |
| ▸ | HRH1 | P35367 | 2/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493434 | 0.88 | HTR7 (0.58) | HTR7MEN1KMT2ADRD2DRD4 | |
| SCHEMBL2492921 | 0.87 | MEN1 (0.59) | HTR7MEN1KMT2ADRD2DRD4 | |
| SCHEMBL13284339 | 0.86 | MEN1 (0.79) | MEN1KMT2ADRD2HRH3ALDH1A1 | |
| SCHEMBL3161038 | 0.85 | MEN1 (0.82) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL15937713 | 0.84 | HTR7 (1.00) | HTR7KMT2ADRD2DRD4DRD3 | |
| SCHEMBL12856249 | 0.81 | MEN1 (0.72) | MEN1KMT2ADRD2HRH3ALDH1A1 | |
| SCHEMBL9831188 | 0.79 | KDM4E (0.69) | MEN1KMT2AHRH3ALDH1A1TSHR | |
| SCHEMBL22810443 | 0.79 | KMT2A (0.71) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL6791318 | 0.78 | HTR7 (0.59) | HTR7MEN1KMT2ADRD2DRD4 | |
| SCHEMBL11849036 | 0.78 | ALDH1A1 (0.55) | HTR7MEN1KMT2ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |