SCHEMBL6793327

SCHEMBL6793327

O=C(Nc1ccc(OCCc2ccccn2)cc1)c1ccccc1-c1ccc(C(F)(F)F)cc1

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMO Q99835 2/20 0.59
TRPV1 Q8NER1 1/20 0.53
NR3C1 P04150 1/20 0.46
APOB P04114 6/20 0.46
MTTP P55157 6/20 0.46
POLB P06746 1/20 0.46
GAA P10253 1/20 0.46
ALDH1A1 P00352 1/20 0.46
KDR P35968 1/20 0.46
EGLN1 Q9GZT9 1/20 0.45
LMNA P02545 1/20 0.45
HTT P42858 1/20 0.45
PTGS1 P23219 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6794029 0.90 MAPT (0.49) SMOTRPV1POLBGAAKDR
SCHEMBL6800981 0.90 SMO (0.60) SMOTRPV1NR3C1APOBMTTP
SCHEMBL6906387 0.90 SMO (0.50) SMOTRPV1APOBMTTPPOLB
SCHEMBL6490835 0.89 SMO (0.50) SMOTRPV1NR3C1APOBMTTP
SCHEMBL6499684 0.89 SMO (0.50) SMOTRPV1NR3C1APOBMTTP
SCHEMBL7080705 0.89 SMO (0.49) SMOTRPV1NR3C1APOBMTTP
SCHEMBL6794869 0.88 SMO (0.56) SMOTRPV1NR3C1APOBMTTP
SCHEMBL6801341 0.87 SMO (0.61) SMOTRPV1NR3C1APOBMTTP
SCHEMBL6788368 0.87 SMO (0.61) SMOTRPV1NR3C1APOBMTTP
SCHEMBL6795238 0.87 SMO (0.47) SMOTRPV1APOBMTTPPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US claimed
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 SMO 2094/4885TRPV1 3714/4885NR3C1 1665/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.