SCHEMBL6794029

SCHEMBL6794029

O=C(Nc1ccc(OCCc2ccccn2)cc1)c1ccccc1-c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.49
KDR P35968 1/20 0.49
ABL1 P00519 6/20 0.49
SMO Q99835 2/20 0.48
TRPV1 Q8NER1 1/20 0.47
POLB P06746 1/20 0.46
GAA P10253 1/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
EPHX2 P34913 1/20 0.45
LMNA P02545 1/20 0.45
HTT P42858 1/20 0.45
PPARA Q07869 1/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6795019 0.90 KDR (0.52) MAPTKDRABL1SMOTRPV1
SCHEMBL6793327 0.90 SMO (0.59) KDRSMOTRPV1POLBGAA
SCHEMBL6794939 0.90 HTR2C (0.48) MAPTKDRABL1SMOTRPV1
SCHEMBL6788429 0.87 KDR (0.52) MAPTKDRABL1SMOTRPV1
SCHEMBL6796259 0.84 NPC1 (0.50) MAPTSMOPOLBGAAMEN1
SCHEMBL6906387 0.84 SMO (0.50) MAPTSMOTRPV1POLBGAA
SCHEMBL6800581 0.84 MAPT (0.46) MAPTKDRABL1SMOTRPV1
SCHEMBL6793936 0.82 NPC1 (0.53) MAPTSMOPOLBGAAMEN1
SCHEMBL6793719 0.82 SMO (0.49) MAPTSMOTRPV1POLBGAA
SCHEMBL6794367 0.82 SMO (0.48) MAPTKDRABL1SMOTRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 MAPT 4795/4885KDR 3180/4885ABL1 1839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.