Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MARS1 | P56192 | 1/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.30 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6791782 | 0.91 | PDPK1 (0.33) | PDPK1CDK2OPRD1RORCPLK1 | |
| Trifluoroacetic Acid SCHEMBL6794900 | 0.91 | RORC (0.34) | KDM1APDPK1CDK2OPRD1RORC | |
| Trifluoroacetic Acid SCHEMBL6794064 | 0.91 | NR1H4 (0.33) | PDPK1CDK2OPRD1PLK1BRAF | |
| Trifluoroacetic Acid SCHEMBL6791711 | 0.90 | BRAF (0.38) | KDM1APDPK1CDK2OPRD1PLK1 | |
| Trifluoroacetic Acid SCHEMBL6794225 | 0.89 | PDPK1 (0.35) | PDPK1CDK2OPRD1PLK1 | |
| Trifluoroacetic Acid SCHEMBL1655702 | 0.88 | KDM1A (0.39) | KDM1APDPK1CDK2OPRD1 | |
| Trifluoroacetic Acid SCHEMBL4267112 | 0.88 | KDM1A (0.33) | KDM1APDPK1CDK2OPRD1RORC | |
| Trifluoroacetic Acid SCHEMBL6794890 | 0.87 | RORC (0.36) | KDM1APDPK1CDK2OPRD1RORC | |
| SCHEMBL6793459 | 0.87 | PTGDR2 (0.33) | PDPK1CDK2RORCPLK1LTA4H | |
| Trifluoroacetic Acid SCHEMBL6792875 | 0.86 | GABRA1 (0.34) | PDPK1CDK2OPRD1RORCPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | KDM1A 2843/4885PDPK1 87/4885CDK2 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.