Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6792278 | 0.92 | RORC (0.36) | PDPK1CDK2OPRD1RORCS1PR1 | |
| Trifluoroacetic Acid SCHEMBL6794900 | 0.91 | RORC (0.34) | PDPK1CDK2OPRD1RORC | |
| Trifluoroacetic Acid SCHEMBL1655968 | 0.91 | MPL (0.39) | PDPK1CDK2PLK1S1PR1 | |
| Trifluoroacetic Acid SCHEMBL1658162 | 0.89 | KCNK3 (0.37) | — | |
| Trifluoroacetic Acid SCHEMBL6791782 | 0.88 | PDPK1 (0.33) | PDPK1CDK2PLK1OPRD1RORC | |
| Trifluoroacetic Acid SCHEMBL6799698 | 0.88 | NPC1 (0.36) | PDPK1CDK2OPRD1S1PR1S1PR3 | |
| Trifluoroacetic Acid SCHEMBL1656588 | 0.88 | GABRA1 (0.37) | GABRA1GABRB2PDPK1CDK2BACE1 | |
| Trifluoroacetic Acid SCHEMBL6791711 | 0.87 | BRAF (0.38) | PDPK1CDK2PLK1OPRD1CSNK1D | |
| SCHEMBL6792883 | 0.87 | PLK1 (0.33) | GABRA1GABRB2PDPK1CDK2PLK1 | |
| Trifluoroacetic Acid SCHEMBL6793455 | 0.86 | KDM1A (0.36) | PDPK1CDK2PLK1OPRD1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | GABRA1 3533/4885GABRB2 2582/4885PDPK1 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.