Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.51 |
| ▸ | HTR2A | P28223 | 8/20 | 0.51 |
| ▸ | DRD3 | P35462 | 7/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6795245 | 0.90 | HTR1A (0.53) | HTR1AHTR2ADRD3HTR2CDRD2 | |
| SCHEMBL6766415 | 0.87 | HTR1A (0.51) | HTR1AHTR2ADRD3HTR2CDRD2 | |
| SCHEMBL6792370 | 0.86 | DRD3 (0.53) | HTR1AHTR2ADRD3HTR2CKCNH2 | |
| SCHEMBL6773329 | 0.85 | HTR3A (0.41) | HTR1AHTR2ADRD3HTR2CKCNH2 | |
| SCHEMBL6771603 | 0.84 | HTR1A (0.45) | HTR1AHTR2ADRD3HTR2CKCNH2 | |
| SCHEMBL6770133 | 0.84 | HTR1A (0.49) | HTR1AHTR2ADRD3HTR2CDRD2 | |
| SCHEMBL6766930 | 0.83 | ALDH1A1 (0.51) | HTR1ADRD3KCNH2HTR7DRD1 | |
| SCHEMBL6794870 | 0.82 | HTR1A (0.54) | HTR1AHTR2ADRD3HTR2CDRD2 | |
| SCHEMBL6771800 | 0.81 | ALDH1A1 (0.43) | HTR1AHTR2ADRD3HTR2CKCNH2 | |
| SCHEMBL6770753 | 0.81 | KMT2A (0.51) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |