Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800641 | 0.88 | MTTP (0.46) | DRD3 | |
| SCHEMBL6795245 | 0.87 | HTR1A (0.53) | HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL6771750 | 0.86 | HTR1A (0.42) | HTR1ADRD3HCRTR1HCRTR2POLB | |
| SCHEMBL6767421 | 0.84 | MAPT (0.37) | HTR1APOLBKITALDH1A1MAPT | |
| SCHEMBL6766832 | 0.82 | PKM (0.44) | ALDH1A1MAPT | |
| SCHEMBL6772435 | 0.82 | PDE10A (0.46) | HTR1AALDH1A1MAPT | |
| SCHEMBL6769386 | 0.80 | POLB (0.36) | POLBKIT | |
| SCHEMBL6768217 | 0.80 | ALDH1A1 (0.41) | HCRTR1HCRTR2POLBALDH1A1 | |
| SCHEMBL6767091 | 0.80 | MTTP (0.40) | HCRTR1HCRTR2ALDH1A1MAPT | |
| SCHEMBL6770210 | 0.80 | PDE10A (0.36) | HTR1AALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |