Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9366512 | 1.00 | MEN1 (0.51) | MEN1KMT2AL3MBTL1LMNACYP2C9 | |
| SCHEMBL7397644 | 0.92 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1 | |
| SCHEMBL7397643 | 0.92 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1 | |
| Oxalic Acid SCHEMBL7395703 | 0.88 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1 | |
| SCHEMBL9730026 | 0.82 | MEN1 (0.53) | MEN1KMT2AL3MBTL1LMNACYP2C9 | |
| SCHEMBL2612622 | 0.82 | ALDH1A1 (0.57) | MEN1KMT2AL3MBTL1LMNACYP2C9 | |
| SCHEMBL9730018 | 0.82 | MEN1 (0.53) | MEN1KMT2AL3MBTL1LMNACYP2C9 | |
| SCHEMBL10165810 | 0.80 | LMNA (0.45) | MEN1KMT2AL3MBTL1LMNACYP2C9 | |
| SCHEMBL6794288 | 0.80 | MEN1 (0.51) | MEN1KMT2AL3MBTL1LMNACYP2C9 | |
| SCHEMBL6799689 | 0.79 | L3MBTL1 (0.52) | MEN1KMT2AL3MBTL1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422846-B1 | Aroyl-ureas | WYETH JOHN & BROTHER LTD (GB) | 1994-02-16 | — | — | EP | claimed |
| EP-0422846-A2 | Aroyl-ureas | JOHN WYETH & BROTHER LIMITED (GB) | 1991-04-17 | — | — | EP | claimed |
| EP-0419397-A1 | Substituted urea compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1991-03-27 | — | — | EP | claimed |
| US-6734306-B2 | USEFUL IN THE TREATMENT OF INFLAMMATION, ASTHMA, ALLERGIC RHINITIS, PAIN OR THE LIKE | PFIZER, INC. | 2004-05-11 | — | — | US | disclosed |
| EP-1213289-A1 | N-benzenesulfonyl L-proline compounds as bradykinin antagonists | PFIZER INC. (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-0422846-B1 | Aroyl-ureas | WYETH JOHN & BROTHER LTD (GB) | 1994-02-16 | — | — | EP | disclosed |
| EP-0422846-A2 | Aroyl-ureas | JOHN WYETH & BROTHER LIMITED (GB) | 1991-04-17 | — | — | EP | disclosed |
| EP-0419397-A1 | Substituted urea compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1991-03-27 | — | — | EP | disclosed |