Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804921 | 0.89 | HDAC3 (0.32) | EPHX2HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL16656154 | 0.83 | EPHX2 (0.38) | EPHX2HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL21892036 | 0.79 | CYP1A2 (0.34) | EPHX2CYP1A2 | |
| SCHEMBL13001638 | 0.79 | EPHX2 (0.37) | EPHX2HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL22587960 | 0.78 | EPHX2 (0.35) | EPHX2HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL648724 | 0.77 | CYP1A2 (0.54) | EPHX2CYP1A2HDAC8HDAC3HDAC1 | |
| SCHEMBL865615 | 0.76 | CYP1A2 (0.37) | EPHX2CYP1A2HDAC8HDAC3HDAC1 | |
| SCHEMBL26647656 | 0.76 | HTR2C (0.41) | EPHX2CYP1A2HDAC8HDAC3HDAC1 | |
| SCHEMBL14964618 | 0.76 | DGKA (0.46) | TSHR | |
| SCHEMBL134923 | 0.76 | EPHX2 (0.46) | EPHX2HDAC8HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750219-B1 | HAVING INTEGRIN ALPHA V BETA 3 ANTAGONISTIC ACTIVITY, GP IIB/IIIA ANTAGONISTIC ACTIVITY, AND/OR HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY AND ALSO HAVING EXCELLENT WATER SOLUBILITY | MEIJI SEIKA KAISHA, LTD. (JP) | 2004-06-15 | — | — | US | disclosed |
| EP-1209152-A1 | OMEGA-AMINO-ALPHA-HYDROXYCARBOXYLIC ACID DERIVATIVES HAVING INTEGRIN ALPHA V BETA 3 ANTAGONISM | MEIJI SEIKA KAISHA LTD. (JP) | 2002-05-29 | — | — | EP | disclosed |