Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639992 | 0.82 | MAPT (0.48) | MAOAMAOBCRBNDDB1ALDH1A1 | |
| SCHEMBL17294198 | 0.81 | MAPT (0.46) | MAOAMAOBCRBNDDB1ALDH1A1 | |
| SCHEMBL6380971 | 0.75 | KDM1A (0.51) | MAOAMAOBCA2 | |
| SCHEMBL6381012 | 0.71 | KDM4E (0.48) | ALDH1A1HPGDMAPK1KDM4ETDP1 | |
| SCHEMBL6380792 | 0.71 | MEN1 (0.48) | CRBNDDB1ALDH1A1HPGDMAPT | |
| SCHEMBL472475 | 0.71 | MAPT (0.50) | CRBNDDB1ALDH1A1HPGDMAPT | |
| SCHEMBL31579572 | 0.71 | HAO1 (0.59) | MAOBALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL4629140 | 0.70 | PTPN1 (0.45) | CRBNDDB1ALDH1A1HPGDMAPT | |
| SCHEMBL31579581 | 0.70 | TSHR (0.46) | CRBNDDB1ALDH1A1TP53CA2 | |
| SCHEMBL11167420 | 0.70 | MAPT (0.45) | ALDH1A1MAPTMAPK1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716845-B2 | Barbituric acid derivatives | HOFFMANN-LA ROCHE INC. | 2004-04-06 | — | — | US | disclosed |