Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 5/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.50 |
| ▸ | MMP3 | P08254 | 4/20 | 0.50 |
| ▸ | MMP13 | P45452 | 3/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5924346 | 0.84 | MMP2 (0.38) | KDM1AMMP2MMP9MMP3MMP13 | |
| SCHEMBL1639992 | 0.82 | MAPT (0.48) | KDM1AMMP2MMP9MAOAMAOB | |
| SCHEMBL17294198 | 0.81 | MAPT (0.46) | KDM1AMMP2MMP9MAOAMAOB | |
| SCHEMBL31579405 | 0.80 | KDM1A (0.40) | KDM1AMMP2MMP9MMP3MMP13 | |
| SCHEMBL31579542 | 0.79 | MMP13 (0.56) | MMP2MMP13MAOAMAOBKCNH2 | |
| SCHEMBL6377381 | 0.79 | MMP2 (0.50) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL6385836 | 0.78 | HPGD (0.53) | KDM1AMAOAMAOBCA1CA2 | |
| SCHEMBL6794976 | 0.75 | MAOA (0.45) | MAOAMAOBCA2 | |
| SCHEMBL11585921 | 0.71 | LTA4H (0.52) | KDM1AMAOAMAOBLTA4HTSHR | |
| SCHEMBL31579572 | 0.71 | HAO1 (0.59) | KDM1AMMP2MAOBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025104154-A1 | 5-[2,7-DIAZASPIRO[3.5]NONAN-7-YL]-5-[4-PHENOXYPHENYL]HEXAHYDROPYRIMIDINE-2,4,6-TRIONE DERIVATIVES AS MMP9 INHIBITORS FOR THE TREATMENT OF DRY EYE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-05-22 | — | — | WO | disclosed |
| EP-0989982-B1 | BARBITURIC ACID DERIVATIVES WITH ANTIMETASTATIC AND ANTITUMOR ACTIVITY | ROCHE DIAGNOSTICS GMBH (DE) | 2005-08-17 | — | — | EP | disclosed |
| EP-1153015-B1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| US-6716845-B2 | Barbituric acid derivatives | HOFFMANN-LA ROCHE INC. | 2004-04-06 | — | — | US | disclosed |
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | disclosed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |
| US-6335332-B1 | MATRIX METALLOPROTEASE INHIBITORS; CONTRACEPTIVES, ANTIINFLAMMATORY AGENTS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-01-01 | — | — | US | disclosed |
| EP-1153015-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| US-6265578-B1 | MATRIX METALLOPROTEASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| US-6110924-A | MATRIX METALLOPROTEASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-08-29 | — | — | US | disclosed |
| WO-2000047565-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-08-17 | — | — | WO | disclosed |
| EP-0869947-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023465-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1997-07-03 | — | — | WO | disclosed |