Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639992 | 0.86 | MAPT (0.48) | CA2MAPTMAPK1LMNATP53 | |
| SCHEMBL17294198 | 0.84 | MAPT (0.46) | CA2MAPTMAPK1LMNATP53 | |
| SCHEMBL472475 | 0.78 | MAPT (0.50) | PTPN1CA2MAPTMAPK1LMNA | |
| SCHEMBL19470370 | 0.74 | MAPT (0.42) | PTPN1CA2MAPTMAPK1LMNA | |
| SCHEMBL11167420 | 0.73 | MAPT (0.45) | MAPTMAPK1LMNATP53CYP1A2 | |
| Aminobenzoic Acid SCHEMBL11699808 | 0.73 | CES2 (0.43) | CA2TP53USP2MEN1KMT2A | |
| SCHEMBL6794976 | 0.70 | MAOA (0.45) | CA2MAPTMAPK1LMNATP53 | |
| SCHEMBL6380971 | 0.70 | KDM1A (0.51) | CA2 | |
| SCHEMBL6381012 | 0.69 | KDM4E (0.48) | MAPK1TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL31579581 | 0.69 | TSHR (0.46) | CA2TP53ALDH1A1POLBDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1573000-B1 | CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) | ASTRAZENECA AB (SE) | 2008-05-07 | — | — | EP | disclosed |
| EP-1573000-A2 | CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) | AstraZeneca AB (SE) | 2005-09-14 | — | — | EP | disclosed |
| US-20050037478-A1 | Crystal structure of glutamate racemase (MurI) | ASTRAZENECA AB (SE) | 2005-02-17 | — | — | US | disclosed |
| WO-2004061097-A2 | CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) | ASTRAZENECA AB (SE) | 2004-07-22 | — | — | WO | disclosed |