Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | HTR2B | P41595 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | PRNP | P04156 | 1/20 | 0.50 |
| ▸ | PPIB | P23284 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP27A1 | Q02318 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6795634 | 0.93 | SMN1; SMN2 (0.56) | SMN1; SMN2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6801984 | 0.89 | SIGMAR1 (0.54) | SMN1; SMN2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6796531 | 0.88 | PPIB (0.55) | SMN1; SMN2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6796152 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6799152 | 0.84 | METAP1 (0.49) | SMN1; SMN2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL18815844 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL27081326 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL11809313 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL25633212 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6794626 | 0.81 | METAP1 (0.51) | SMN1; SMN2PRNPPPIBMAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082642-A1 | Novel estrogen receptor ligands and method III | MERCK & CO., INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082642-A1 | Novel estrogen receptor ligands and method III | ESRRA, ESRRB, FSHR | SMN1; SMN2 2695/4885HTR2A 850/4885HTR2C 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.