Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | PPIB | P23284 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6801984 | 0.93 | SIGMAR1 (0.54) | METAP1ADRA2ASMN1; SMN2MAOBDRD2 | |
| SCHEMBL6795634 | 0.91 | SMN1; SMN2 (0.56) | METAP1ADRA2ASMN1; SMN2MAOBDRD2 | |
| SCHEMBL6798898 | 0.91 | SMN1; SMN2 (0.43) | METAP1ADRA2ASMN1; SMN2MAOBDRD2 | |
| SCHEMBL14409344 | 0.88 | HTR2A (0.53) | METAP1SMN1; SMN2MAOBDRD2HTR2A | |
| SCHEMBL6800097 | 0.88 | METAP1 (0.54) | METAP1ADRA2ASMN1; SMN2MAOBCYP19A1 | |
| SCHEMBL8779124 | 0.85 | HTR2A (0.51) | METAP1SMN1; SMN2MAOBDRD2HTR2A | |
| SCHEMBL6796533 | 0.84 | SMN1; SMN2 (0.55) | ADRA2ASMN1; SMN2MAOBDRD2HTR2A | |
| SCHEMBL6796152 | 0.84 | SMN1; SMN2 (0.53) | METAP1ADRA2ASMN1; SMN2MAOBDRD2 | |
| SCHEMBL11805867 | 0.84 | METAP1 (0.47) | METAP1SMN1; SMN2MAOBDRD2HTR2A | |
| SCHEMBL13004977 | 0.83 | SIGMAR1 (0.62) | METAP1SMN1; SMN2MAOBDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082642-A1 | Novel estrogen receptor ligands and method III | MERCK & CO., INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082642-A1 | Novel estrogen receptor ligands and method III | ESRRA, ESRRB, FSHR | METAP1 4145/4885ADRA2A 237/4885SMN1; SMN2 2695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.