Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6791881 | 0.88 | CHRM2 (0.35) | CCNCCDK8HASPINCDK2CCNA2 | |
| SCHEMBL6796772 | 0.87 | CCNC (0.31) | CCNCCDK8HASPINMEN1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6787093 | 0.86 | MCHR2 (0.34) | CCNCCDK8HASPINALDH1A1SMN1; SMN2 | |
| SCHEMBL6787046 | 0.86 | CDK2 (0.38) | CDK2CCNA2CHRM2CHRM4CHRM1 | |
| Trifluoroacetic Acid SCHEMBL4270462 | 0.85 | CDK2 (0.41) | HRH4CDK2CCNA2AURKACCNA1 | |
| Trifluoroacetic Acid SCHEMBL6792620 | 0.85 | ALDH1A1 (0.37) | ALDH1A1CDK2CCNA2AURKACCNA1 | |
| Trifluoroacetic Acid SCHEMBL6793603 | 0.85 | CDK2 (0.33) | CDK2CCNA2AURKACCNA1PDPK1 | |
| SCHEMBL6793396 | 0.85 | NAMPT (0.36) | ALDH1A1CDK2CCNA2CHRM1AURKA | |
| SCHEMBL6793766 | 0.85 | CCNA2 (0.39) | CDK2CCNA2CHRM2CHRM4CHRM3 | |
| Trifluoroacetic Acid SCHEMBL6793544 | 0.84 | CDK2 (0.35) | ALDH1A1CDK2CCNA2AURKACCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | CCNC 291/4885CDK8 181/4885HASPIN 764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.