Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499090 | 0.92 | CA2 (0.44) | HDAC1HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL10791125 | 0.90 | PRKCA (0.46) | HDAC1HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL11161603 | 0.89 | HDAC1 (0.46) | HDAC1HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL10787330 | 0.88 | TDP1 (0.40) | HDAC1HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL10787834 | 0.88 | PRKCA (0.45) | HDAC1HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL10786520 | 0.85 | ALDH1A1 (0.53) | HDAC1HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL19678473 | 0.85 | ALDH1A1 (0.53) | ALDH1A1LMNACA1CA2SMN1; SMN2 | |
| SCHEMBL7927514 | 0.85 | ALDH1A1 (0.53) | ALDH1A1LMNACA1CA2SMN1; SMN2 | |
| SCHEMBL30530210 | 0.85 | ALDH1A1 (0.53) | ALDH1A1LMNACA1CA2SMN1; SMN2 | |
| SCHEMBL2047105 | 0.85 | ALDH1A1 (0.53) | ALDH1A1LMNACA1CA2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023056948-A1 | METHODS FOR TREATING SPINOCEREBELLAR ATAXIA TYPE 1 (SCA1) WITH VALPROATE (VPA) COMPOUNDS | HANGZHOU JIJING PHARMACEUTICAL TECHNOLOGY LIMITED (CN) | 2023-04-13 | — | — | WO | disclosed |
| WO-2023056606-A1 | VALPROATE (VPA) COMPOUNDS FOR USE IN TREATING SPINOCEREBELLAR ATAXIA TYPE 1 (SCA1) | HANGZHOU JIJING PHARMACEUTICAL TECHNOLOGY LIMITED (CN) | 2023-04-13 | — | — | WO | disclosed |
| US-9463173-B2 | Compositions and methods for treating obesity and obesity-related conditions | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-10-11 | — | — | US | disclosed |
| US-20150250747-A1 | COMPOSITIONS AND METHODS FOR TREATING OBESITY AND OBESITY-RELATED CONDITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-10 | — | — | US | disclosed |
| US-20120003191-A1 | VALPROIC ACID, DERIVATIVES, ANALOGUES, AND COMPOSITIONS INCLUDING SAME AND METHODS FOR THEIR THERAPEUTIC USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-01-05 | — | — | US | disclosed |
| WO-2010080581-A2 | VALPROIC ACID, DERIVATIVES, ANALOGUES, AND COMPOSITIONS INCLUDING SAME AND METHODS FOR THEIR THERAPEUTIC USE | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) | 2010-07-15 | — | — | WO | disclosed |
| US-7713550-B2 | Controlled release sodium valproate formulation | ANDRX CORPORATION (US) | 2010-05-11 | — | — | US | disclosed |
| US-20050276850-A1 | Controlled release sodium valproate formulation | ANDRX CORPORATION | 2005-12-15 | — | — | US | disclosed |
| EP-0430287-B2 | Sustained-release drug dosage units | ABBOTT LAB (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5268182-A | Coating contains ethyl cellulose or methyl methacrylate; plasticizer and detackifying agent | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| US-5169642-A | Coating of ethyl cellulose and(or) methyl methacrylate with plasticizer and detackifier agent | ABBOTT LABORATORIES (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0442012-A1 | Sustained release compositions containing valproic acid | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1991-08-21 | — | — | EP | disclosed |
| EP-0430287-A2 | Sustained-release drug dosage units | ABBOTT LABORATORIES (US) | 1991-06-05 | — | — | EP | disclosed |
| US-4913906-A | DRUG DELIVERY; UNIFORM MIXTURE WITH POLYMER; ALSO SALTS, AMIDES, ESTERS | ABBOTT LABORATORIES | 1990-04-03 | — | — | US | disclosed |
| US-4654370-A | TREATING EPILEPTIC SEIZURES | ABBOTT LABORATORIES (US) | 1987-03-31 | — | — | US | disclosed |
| US-4423071-A | ANOXIA, ANTICONVULSANTS, GLYCERYL BIS-(DI-N-PROPYLACETATES) | SANOFI (FR) | 1983-12-27 | — | — | US | disclosed |