Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.34 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | GPR6 | P46095 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845474 | 0.91 | HPGDS (0.38) | HSP90AA1HSP90AB1HSP90B1TRAP1PDE1B | |
| SCHEMBL6800033 | 0.90 | GRM5 (0.38) | HSP90AA1HSP90AB1HSP90B1TRAP1PDE1B | |
| SCHEMBL6795536 | 0.88 | PDE1B (0.37) | PDE1BHPGDSPDE1APDE1C | |
| SCHEMBL6797534 | 0.87 | PDE1B (0.36) | HSP90AA1HSP90AB1HSP90B1TRAP1PDE1B | |
| SCHEMBL5844055 | 0.87 | PDE1B (0.36) | HSP90AA1HSP90AB1HSP90B1TRAP1PDE1B | |
| SCHEMBL6797756 | 0.86 | HPGDS (0.35) | HSP90AA1HSP90AB1HSP90B1TRAP1PDE1B | |
| SCHEMBL6799775 | 0.80 | LRRK2 (0.38) | PDE1BHPGDSPDE1APDE1C | |
| SCHEMBL6792201 | 0.78 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1HSP90B1TRAP1PDE1B | |
| SCHEMBL6799142 | 0.77 | LRRK2 (0.36) | HSP90AA1HSP90AB1HSP90B1TRAP1PDE1B | |
| SCHEMBL6799139 | 0.77 | LRRK2 (0.36) | HSP90AA1HSP90AB1HSP90B1TRAP1PDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833378-B2 | Pyridines, pyrimidines, purinones, pyrrolopyrimidinones and pyrrolopyridinones; useful in the treatment disorders including CNS and stress-related disorders. | PFIZER INC | 2004-12-21 | — | — | US | disclosed |
| US-20020016328-A1 | Corticotropin releasing factor antagonists | PFIZER INC. | 2002-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016328-A1 | Corticotropin releasing factor antagonists | CRH, CRHR2, CRHR1 | MCHR1 51/4885HSP90AA1 2801/4885HSP90AB1 2668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.