Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28130803 | 0.85 | NPC1 (0.51) | NPC1LOXL2LRRK2HDAC6GRM5 | |
| SCHEMBL934411 | 0.81 | NOS1 (0.51) | NPC1LRRK2HDAC6CYP3A4GRM5 | |
| SCHEMBL5992317 | 0.80 | LOXL2 (0.63) | CACNA1BLOXL2LRRK2HDAC6GHSR | |
| SCHEMBL10078294 | 0.80 | LOXL2 (0.63) | CACNA1BLOXL2LRRK2HDAC6GHSR | |
| SCHEMBL16591628 | 0.77 | NPC1 (0.67) | NPC1KDM4EALDH1A1HPGDCA12 | |
| SCHEMBL16586060 | 0.77 | NPC1 (0.67) | NPC1HDAC6KDM4C | |
| SCHEMBL454284 | 0.77 | NPC1 (0.67) | NPC1HDAC6KDM4C | |
| Hydrochloric Acid SCHEMBL6297807 | 0.76 | NPC1 (0.70) | NPC1HDAC6KDM4C | |
| SCHEMBL510619 | 0.75 | HTT (0.58) | CACNA1BLOXL2GHSRKDM4EALDH1A1 | |
| SCHEMBL24496667 | 0.75 | NPC1 (0.63) | NPC1CYP3A4GRM5CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1308297-C | Phenyl sulfamate derivs. | TEIKOKU HORMONE MFG CO LTD (JP) | 2007-04-04 | — | — | CN | disclosed |
| US-6762205-B1 | STEROID SULFATASE INHIBITORS WITHOUT ESTROGENIC SIDE EFFECT ACTION | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2004-07-13 | — | — | US | disclosed |
| CN-1360570-A | Phenyl sulfamate derivs. | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-07-24 | — | — | CN | disclosed |
| EP-1193250-A1 | PHENYL SULFAMATE DERIVATIVES | Teikoku Hormone Mfg. Co., Ltd. (JP) | 2002-04-03 | — | — | EP | disclosed |